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In a study involving 44 participants aged 20-62, researchers observed after four weeks of daily consumption of the probiotic DE111 at 1 billion CFU a significant decrease in the basal levels of several immune cell populations, including CD3+ T cells, cytotoxic T cells, and NKT cells. Moreover, the probiotic group showed an increased capacity for immune response in cells stimulated by an induced inflammation. The results suggests that DE111 may modulate the immune system through action on both innate (rapid response) and adaptive (slow response) immune cell types.