Skip to main content

Collective research on the genetic and mechanistic abilities of the probiotic DE111® has been published in Frontiers of Microbiology.  This work, entitled “In vitro and in silico assessment of probiotic and functional properties of Bacillus subtilis DE111®”, supports the demonstration of health benefits observed in previous clinical studies performed with this strain of Bacillus subtilis.

Using a combination of in vitro functional assays and genome analysis, researchers found that DE111® demonstrated the ability to survive harsh conditions such as those found in the GI tract, as well as pasteurization.  It also stimulated release of short-chain fatty acids, which support healthy lower GI function, as well as an increase in enzymatic activity (such as proteases, peptidases and esterases) and carbohydrate metabolism, pointing to its ability to promote a more efficient digestive process. Additionally, researchers observed the strain’s ability to outcompete several types of unwanted bacteria associated with urinary, skin and intestinal imbalances.